Their life on the lam (as explained in the theme song) eventually leads to them hiding out in a pet store and being purchased by Elmyra Duff.
This short-lived series continued the exploits of Pinky and The Brain, who had now been evicted from the now-burned-down Acme Labs (in one episode, it was revealed that the lab had been turned into a Disney Store) and on the run from the psychotic Wally Faust, a parody of actor Christopher Walken, who had been parodied on the show several times before.
Nickelodeon apparently held syndication rights to Pinky, Elmyra and the Brain as part of their purchase of the Pinky and the Brain Syndication Package but there is no record of the show airing on either Nickelodeon or Nicktoons, suggesting that not even they wanted to air it.
In the time period where Elmyra initially took place, Brain begins a 22-year long plan at his home of a gradually-updating Acme Labs. To further hit the nail in the coffin, the first Pinky and the Brain segment of the Animaniacs revival, " Of Mice and Memes", essentially erases the entire series. It has been alluded by Tom Ruegger that the series is set in a mirror-universe where the events of the prior series occurred, but a series of different events render the show “non-canon” to the main universe.
In total, the thirteen episodes of this spin-off plus the sixty-five episodes of the main series add up to 78 total episodes of the Pinky and the Brain series. The show was cancelled after one season due to bad ratings and the later episodes were aired on The Big Cartoonie Show. for Disney in 1997, with his final story being the episode " You'll Never Eat Food Pellets In This Town Again". The series' writers were not at all happy with these demands, to the point that Peter Hastings left Warner Bros. It was created as result of The WB Network executives demanding to change Pinky and the Brain to have less focus on world domination and adding another main character. Steven Spielberg presents Pinky, Elmyra and the Brain (originally titled The Continuing Adventures of Pinky and the Brain and Pinky and the Brain: The Elmyra Years) is a spin-off series of Pinky and the Brain, starring the two characters alongside Elmyra Duff from Tiny Toon Adventures. It’s what the network wants, why bother to complain!?